Metagenomic surveillance of hawker centres in Singapore
A hawker center in Singapore (from wikipedia.org).

Excited to share our work on city-wide metagenomic surveillance of hawker centres in Singapore!

Several surprising findings here.

Firstly, in addition to finding microbial DNA, we found plenty of non-microbial DNA, most of which looked like it had a food origin. We used this to identify food-microbe associations.

Secondly, we noticed that each hawker centre seems to have a unique microbial fingerprint, which in some cases can be largely preserved over many years

Finally, we found that hawker centres may be surprisingly enriched for antibiotic resistance genes and clinically-relevant pathogens, in some cases more than even hospital environments!

Metagenomic surveillance of hawker centres in Singapore
Older post

Identifying gut microbial hallmarks of healthy aging

Shotgun metagenomics data for >200 healthy Asian octogenerians helped us identify key gut microbial hallmarks of healthy aging, including some that are only consistently seen in Asian cohorts!

Newer post

Deciphering non-canonical bases in nanopore sequencing data with AI

We developed a fast and accurate method for sequencing non-canonical bases, enabling applications in data storage, nucleic acid therapeutics, and synthetic biology.

Metagenomic surveillance of hawker centres in Singapore